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Higher iron levels are another characteristic of CSCs, such that ferroptosis may be a good method for eliminating CSCs, which are less susceptible to classical anticancer apoptosis-inducing agents

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doi: 10.3389/fmed.2025.1538194 Received 20 December 2024 Accepted 22 April 2025 Published 09 May 2025 Volume 12 - 2025 Edited by Claudia Fiorillo, University of Florence, Italy Reviewed by Sabina Galiniak, University of Rzeszw, Poland Juan Luis Santiago, Poland Universitario de Ciudad Real, Spain Hiroki Satooka, Shiga University of Medical Science, Japan Jie Zhang, Kunming University of Science and Technology, China Updates Copyright 2025 Luo, Hu, Zhou, Zhang, Wu and Sun

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Consequently, the onset of ferroptosis within RPECs can trigger PR damage, potentially culminating in their death