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Kapogiannis D

Preclinical research has demonstrated multiple effects of DSIP across various experimental models: Sleep Architecture Modifications Animal studies involving rodents and cats have shown that when DSIP is administered, there are significant changes in sleep-wake patterns

Amy Arnstens group showed that it acts on the dendritic spines of prefrontal neurons by closing HCN ion channels, raising the gain of the networks that hold information in mind while the drug is present

Zhang J, Hu M, Teng Z, Tang YP, Chen C (2014) Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimers disease