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274 Diabetes Although no clear clinical evidence is available that disordered p53 directly promotes type I diabetes, dysfunctional p53 can induce critical biological processes in diabetes, including disturbances in glucose homeostasis at the organismal level, pancreatic -cell deficiency, and insulin resistance in peripheral tissues

Ca 2+ - and Zn 2+ -ions have opposite effects on the stability of S100A2, with Ca 2+ acting as a protein stabilizer and Zn 2+ as a protein destabilizer (43)