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Animal experiments reported reduced retinal Cu/Zn SOD activity in DR rats, causing mitochondrial oxidative injury, morphological swelling, and blurred mitochondrial cristae boundaries (184)

More recently, triple artemisinin-based combination therapy has emerged to address ACT resistance [5,6,7], but a critical unresolved question remains: how to select optimal partner drugs to maximize therapeutic efficacy

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The safety data comes primarily from animal studies, with human use data coming from clinical practice rather than formal trials

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