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Reactive oxygen species in metabolic and inflammatory signaling

Code availability Customized codes to reproduce the integration pipeline, figures and downstream analysis were deposited on a GitHub repository (www.github.com/susztaklab/SISKA

15 , e8746 (2019)

Typical values of GSH in animal cells are in the range 50010,000 M or 0.510 mM [1, 39]

In conclusion, the accumulation of specific uremic toxins in CKDsuch as indoxyl sulfate, phosphate, vanadate, and acroleinpromotes eryptosis through distinct but convergent mechanisms involving Ca 2+ dysregulation, oxidative stress, energy depletion, and kinase activation