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The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]

Conclusion: In this study, we extracted Sig dMMR as the simple value representing the dMMR-associated mutational feature from the complicated big data of WGS of each HCC or liver tisssue sample

Model building and refinement To obtain the atomic models for MARV and EBOV polymerase complexes, the cryo-EM maps at atomic or near-atomic resolutions were used for automated and de novo model building by ModelAngelo 58