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The EGFR/ErbB3 pathway acts as a compensatory survival mechanism upon c-Met inhibition in human c-Met+ hepatocellular carcinoma

Continuous daily dosing maintains steady-state synaptogenesis, while cyclic protocols (5 days on, 2 days off, or 4 weeks on, 1 week off) are used to assess whether newly formed synapses persist after Dihexa withdrawal