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The two variations of MTHF-R mutation discussed in this article, the A1298C and C677T mutations, have been linked to conditions such as anxiety, migraines, fibromyalgia, ADD/ADHD, dementia, deep vein thrombosis, heart disease, elevated blood pressure, peripheral neuropathy, elevated liver enzymes, elevated cholesterol, infertility and miscarriages, to name a few

Functionalized nanocarriers engineered from diverse materials, including liposomes, polymeric nanoparticles, and nanogels, can be tailored with targeting ligands to further improve brain-targeting efficiency, optimize therapeutic outcomes, and minimize off-target effects

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