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1,25-Dihydroxyvitamin D3 reduces TGF-3-induced fibrosis-related gene expression in human uterine leiomyoma cells

(2020) 8(8):CD007807

When you start taking collagen, your body might begin repairing tissues and flushing out toxins that have been sitting under the surface

In enhancing migration and metastasis of cancer cells, TGF- induces EMT through Smad4 upregulation (Xiong et al., 2020)

Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach