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Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes

Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)

Notably, nutrient deprivation-induced ERS also influences the tumor immune microenvironment, transmitting regulatory signals via exosomes and other carriers to suppress T-cell function and promote the polarization of immunosuppressive M2-type macrophages [24]

The PML/RAR oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

Lin X, Zhan B, Wen S, Li Z, Huang H, Feng J