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In this answer 3 sections The reason you started with intense every other day B12 shots and transitioned to a monthly schedule is a medical strategy called loading and maintenance. When you were first diagnosed, your bodys B12 stores were dangerously low

If the volume of the red methyl-B12 shot is large enough, the next urine specimen will be red or it will be some color of red depending on the concentration of the urine

We will discuss concerns you have, particularly about difficulty losing weight or persistent feelings of low energy or sluggishness

Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B 12 , irreversible damage will result

Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms