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The GSH and GSSG amount was evaluated using GSH/GSSG assay kit

These systems allow targeted delivery of therapeutic nucleic acids, such as GPX4 mRNA to enhance antioxidant capacity or ACSL4-siRNA to limit peroxidation-prone lipid pools (164), enabling cell-type-specific suppression of ferroptosis

He was a retired construction worker

[DOI] [PMC free article] [PubMed] [Google Scholar] 389.Scarangella A, Soldan V and Mitov M, Nat

Lifestyle interventions that reshape ROS tone (mechanism-anchored) Lifestyle levers can reset ROS tone in ways drugs often cant: exercise training induces mitochondrial biogenesis and mitophagy, improves endothelial NO bioavailability and upregulates endogenous antioxidant systems so that the pulsatile ROS generated during bouts acts as a mitohormetic signal rather than a damaging load (Guan et al