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Current research focuses on counteracting HO-1-mediated ferroptosis through the following strategies: using HO-1 inhibitors (e.g., zinc protoporphyrin-IX (ZnPP)), ferroptosis inhibitors (e.g., ferrostatin-1, iron chelators), modulating key signaling pathways (e.g., targeting the Nrf2/Keap1 axis), and microRNA-mediated inhibition (e.g., miR-24, miR-200c) (69)

It was also reported that icariin and irisin protect against myocardial and lung injury, respectively, by suppressing H/R-induced ferroptosis of cardiomyocytes and lung epithelial cells via activating Nrf2/HO-1 signaling [161,162]

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Int J Environ Clim Change 12(7):140148 Taghavi S, van der Lelie D, Hoffman A, Zhang Y-B, Walla MD, Vangronsveld J, Newman L, Monchy S (2010) Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp