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Olive JK, Zhou N, Mitchell KG, Corsini EM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Antonoff MB

however, an association between vitamin C/SVCT2 and neurogenic cells (alpha-tanycytes or median eminence stem cells) has never been studied

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In some cases, the affinity optimization is aimed at increasing the affinity by at least 2-fold, at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, at least 10-fold, at least 20-fold, at least 30-fold, at least 40-fold, at least 50-fold, at least 100-fold, at least 500-fold, or at least 1,000-fold or more as compared to the affinity of the original antibody