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As such, GSH depletion by H

Lipid peroxidation: chemical mechanism, biological implications and analytical determination, in Lipid peroxidation

Sustained or repeated fluxes saturate local peroxiredoxins and glutathione pools, spill into iron-rich chromatin niches and bias toward ONOO and Fenton chemistry that disrupt transcription

The results exhibited that Fer-1 treatment inhibited the PA-induced iron deposition and steatosis and reduced the levels of IL-6, TNF-, Collagen I and -SMA expression in primary hepatocytes