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Conversely, if GSSG oxidizes PDI, then the net result would be an increase in the concentration of GSH relative to GSSG

While eicosanoids derived from EPA are less biologically active than AA-derived eicosanoids (37), supplementation with EPA and other n-3 PUFAs may nevertheless have utility in treating various inflammatory diseases

Elevated Growth/differentiation factor 15 (GDF15) level in serum and increased GDF15 expression in cancer tissues are reported in patients with various cancers, and associated with the poor prognosis of the patients (Welsh et al., 2001

however, high homocysteine levels have been found to be correlated with PCOS diagnosis independently of other indicators of cardio-metabolic risk

Therefore, we designed a dual ferroptosis amplification strategy using an iron-based MOFs that combined iron supply and de novo GSH elimination for effective ferroptosis management