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However, the signal-to-noise from 13C-MRS is such that human studies generally require very large regions of interest and long acquisitions (over half of the frontal lobe for 120 min [139], contrasted with 5 to 10 min for single voxel 1 H-MRS and 17 min for EPSI)

Extensive resection is linked to improved survival in both LGGs and HGGs, 332 although the precise correlation between the extent of resection and patient outcomes requires further study