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When lncRNA PVT1 expression is decreased, the probability of ferroptosis in liver cancer cells is greatly increased

Although these two-dimensional systems cannot fully recapitulate the biomechanical complexity or three-dimensional architecture of the native myocardium, their high reproducibility, scalability, and compatibility with industrial screening workflows render them indispensable for initial cardiotoxicity assessment 25

10.1152/ajpendo.00223.2012 11 FrosenJ

Stressed or damaged tissue cells release NAD+ into the extracellular space, which is then utilized by adenosine diphosphate ribosyl transferase 2.2 (ART2.2), a glycosyl-phosphatidylinositol-anchored ectoenzyme expressed on T cells, to transfer ADP-ribose to arginine residues of extracellular domains of surface proteins, a process known as ADP-ribosylation