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Excessive methylglyoxal is detoxified in part by glyoxalase I, which converts methylglyoxal into S-D-lactoylglutathione in the presence of glutathione (Inoue and Kimura, 1996)

Dihydroorotate dehydrogenase is involved in pyrimidine synthesis and uses riboflavin as flavin mononucleotide (FMN) instead of FAD, while mitochondrial glycerol 3-phosphate dehydrogenase depends on FAD like all the red enzymes