10.1038/ismej.2010.129 251 SenderR.FuchsS.MiloR
This approach addressed the limitations of relying solely on computational predictions, which can sometimes overlook critical biological nuances
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GLP-1Rs, when activated, depolarize (stimulate) proopiomelanocortin/cocaine-and amphetamine-regulated transcript pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript neurons and hyperpolarize (inhibit) NPY/agouti-related peptide neurons
Both represent a step beyond current FDA-approved options
