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Conclusions In conclusion, the developed model integrating clinical features cfDNA, and genetic variants demonstrated promising potential for predicting high-risk GDM among Chinese pregnant women in early pregnancy

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Author contributions Conceptualization: IDG, OB, LB Methodology: IDG, OB, MPM, RB, GDS, LB Investigation: IDG, OB, MPM, RB, LB Visualization: IDG, OB Supervision: LB Writingoriginal draft: IDG, LB Writingreview & editing: IDG, OB, MPM, RB, GDS, LB Competing interests Authors declare that they have no competing interests Data and materials availability All data supporting the findings of this study are included within the article or are available from the authors upon reasonable request