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This in turn inhibits the transcription of mitochondrial ribosome-encoding genes and mitochondrial biogenesis, leading to cardiomyocyte apoptosis and cardiac fibrosis

The formation of urinary CaOx crystals is closely associated with supersaturation of oxalate and calcium ions, as well as injury to the tubular epithelium [4, 5]

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Wagner, Susan M

Furthermore, metabolites also play a regulatory role in the function of different immune cells involved in psoriasis pathogenesis, particularly T lymphocytes