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qtot 0.403 53 HGPAM1 1 ful H53 53 0.349 1.008

The results indicated a significant reduction in cell proliferation and an increase in oxidative stress and apoptosis, which were also associated with the SiO2 NP concentration

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In previous work, we have shown in mice that inhibitors selective for bacterial GUS alleviated SN-38 dose limiting diarrhoea and reduced the number of NSAID-induced small intestinal ulcers, further suggesting that GUS enzymes give rise to undesired GI side effects by reversing Phase II glucuronidation 17,18,19

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