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Studies indicate that quercetin can hinder apoptosis in chondrocytes by obstructing the MAPK signaling pathway [43]

So any disease states that affect perfusion of the organs (specifically the liver in this case) can affect metabolism of warfarin and increase sensitivity to the drug

Animal models Standard mouse models include accelerated aging mice (SAMP8, SAMP10), progeria models (LAKI), telomerase knockouts (Terc-/-) and transgenic mice expressing senescent markers (p16-luciferase, p16-3MR for inducible elimination)