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Konkretne kierunki badawcze obejmuj: Metabolizm energetyczny tkanki tuszczowej badania nad wpywem inhibicji NNMT na wydatek energetyczny adipocytw i gospodark lipidow w modelach otyoci O nikotynamid/NAD pomiary, jak hamowanie metylacji nikotynamidu przekada si na dostpno substratu do regeneracji NAD przez szlak ratunkowy Gospodarka grupami metylowymi analiza wpywu inhibicji NNMT na bilans SAM/SAH i wtrnie na inne reakcje metylacji Regeneracja i masa miniowa badania nad rol NNMT w komrkach satelitarnych mini szkieletowych Zalenoci struktura-aktywno (SAR) charakterystyka 5-Amino-1MQ jako reprezentanta maoczsteczkowych inhibitorw NNMT w analizach porwnawczych W projektowaniu eksperymentw porwnawczych nad metabolizmem tkanki tuszczowej 5-Amino-1MQ bywa zestawiany z compoundami o odmiennym punkcie zaczepienia na przykad z lipolitycznym fragmentem hormonu wzrostu AOD-9604 czy doustnym agonist inkretynowym GLP-1 MAX

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J Expo Sci Environ Epidemiol

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This 30-second step prevents contamination that could make days of reconstituted peptide unusable

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86 FR 65273 through 65279

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