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gene locus Xq28) arranged in a 2:1:1 ratio ( 2+ , adenine dinucleotide phosphate (ADP), citrate) and negative effectors (ATP, NADH, NADPH)

O., Milligan, W., Lochhead, P

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Although various bio-safety evaluations have provided a series of evidences that MSNs are biocompatible in vivo within desirable dose and they can be degraded and expelled from the body via urine and feces 58,59,60,61 , there remain many challenges that need to be overcome since the in vivo therapeutic use requires more strict performance modulation to satisfy the complicated physiological environment so as to avoid unwanted bio-performances of MSNs