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in suppressed p62, KEAP1 is known to increase cell growth and resistance to ROS via nuclear factor erythroid 2-related factor 2 (NRF2) activation (Tkachev et al., 2011

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While glyoxalase II substrate S-D-lactoylglutathione (SLG) acts as a precursor of the D-lactyl moiety for non-enzymatic D-lactylation, highlighting the multifaceted characteristics of lactylation as a biological regulatory system consisting of substrate specificity, lactate source, and enzyme dependence