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Paclitaxel-induced mitotic stress leads to cleavage of procaspases and activation of the caspase cascade, effectively executing programmed cell death (99)

The observed lesions such as rapture, sloughing off of meninges, and hemorrhage was indicative of primary injury while the inflammatory responses that may cause neuronal loss, axonal injury, and impairment of synaptic plasticity indicate the secondary injury process (Andres et al., 2014)