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23 In central sleep apnea, however, the brain does not adequately respond to the excitatory signals that trigger respiration, including carbon dioxide levels, and regulation of breathing is disrupted

Although the details of the molecular mechanisms of the Nrf2-mediated response to electrophile stress remain to be elucidated, it seems somewhat provocative to suggest that, at low concentration, acrolein may actually exert cytoprotective effects by inducing phase II enzymes via activation of Nrf2 [119]