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40 CMA normally clears SNCA, but mutations (A53T/A30P) and reduced LAMP2A impair this process

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Proteins such as G protein-coupled receptors, PI3K, AKT, MMPS, EGFR, VEGF, ERK, STAT3, p53, FOX, JNK, caspases, JAK, PKC, FGF, Nrf2, ALK, ROS1, mTOR, and MAPK are pivotal derivers in the pathogenesis of human cancers (386, 392)