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Gene ontology analysis of the gene set from cluster 1 revealed a significant enrichment of gene ontology terms associated with critical cellular processes, including dopaminergic synaptic transmission, prepulse inhibition and enriched biological processes (like locomotor behaviour and drug response) (Extended Data Fig

Development of disease models: Many diseases, especially brain tissue disorders, lack reliable experimental models

In type 2 diabetes mellitus (T2DM) and metabolic syndrome, mitochondrial dysfunction is a key pathogenic driver contributing to impaired insulin signaling, ectopic lipid accumulation, and chronic low-grade inflammation [66]

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