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InterPro analysis showed that SapM possesses a signature match to the phosphoesterase domain that is present in the superfamily of alkaline phosphatases 22,23 and in the superfamily of acid phosphatases and phospholipases C (PLC/phosphatase superfamily) 24 .A prototype of classic alkaline phosphatases (AlkPs) is the Escherichia coli alkaline phosphatase (Ec-AlkP) 25 , which shares 23% sequence similarity (16% identity) to SapM (Fig