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Animal studies using Alzheimers disease models have also shown that vitamin C deficiency in the brain can disrupt redox balance and accelerate the production of amyloid-beta, a key trigger of oxidative stress in Alzheimers pathology

84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease