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As previous suggested, the above-mentioned spidery strong- Mbp + (type 2) cells are actually the newly-forming/formed OLs that are largely overlapped with the population of Enpp6 positive cells (Xiao et al., 2016)

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The reduced activity of antioxidant enzymes in the body results in DNA hydroxylation, protein denaturation, increased lipid peroxidation, and impairment of cellular functions, disrupting the conditions necessary for cell survival

Moreover, melatonin controls dopamine signaling in the forebrain, hypothalamic and hippocampal areas ( Several clinical studies tried to identify alterations in absolute levels of melatonin as a possible maker of depressive states

Exercise/resistance training: Resistance exercise preserves lean mass in cachexia