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It bypasses first-pass metabolism

It has been observed using in vitro cell culture studies that the nascent amyloid is nontoxic but aged amyloid becomes toxic to neurons [110]

doi: 10.3389/fphar.2022.854674 Received 14 January 2022 Accepted 07 February 2022 Published 03 March 2022 Volume 13 - 2022 Edited by Francisco Javier Cubero, Complutense University of Madrid, Spain Reviewed by Hyeong-Geug Kim, Indiana University, United States Xiu Zhou, Wuyi University, China Updates Copyright 2022 Zhang and Feng

Hiddinga HJ, Sakagashira S, Ishigame M et al (2012) Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

10.1105/tpc.109.070219 Plant Cell 38 LatifiA.RuizM.ZhangC