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this enhances the elaboration of proinflammatory cytokines and enzymes for ECM degradation and leads to cartilage damage (Han et al., 2025)

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The serum changes of 6 metabolites involved in glucose metabolism, including increased glycerol-3-phosphate, lactate, citrate, and decreased pyruvate, 2-oxoglutarate, 2-hydroxyglutaric acid (2-HG), have independent prognostic values in AML patients, in which poor prognosis was linked to accelerated glycolysis and activation of the TCA cycle (132)

10.1016/s0304-4165(00)00035-0 BBA Gen