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Targeted Therapy and Surgery for Advanced Differentiated Thyroid Cancer

An increase in growth hormone levels has been associated with improved cell proliferation due to telomere shortening and a reduction in cellular death due to a decline in processes such as oxidative stress

Additionally, production of ROS (primarily O 2 and H 2 O 2 ) occurs when molecular oxygen is reduced by mainly electron leakage in mitochondrial complex I and III (about 15% of oxygen is converted to H 2 O 2

Biochem Pharmacol 66:297306 Messer RL, Lockwood PE, Tseng WY, Edwards K, Shaw M, Caughman GB, Lewis JB, Wataha JC (2005) Mercury (II) alters mitochondrial activity of monocytes at sublethal doses via oxidative stress mechanisms

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