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5 Clinical application prospects The gut microbiome and its metabolites have emerged as actionable modulators of the gut-tumor-immune axis, offering a framework to enhance cancer immunotherapy efficacy through targeted microbial manipulation

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Therefore, reduced levels of -ketoglutarate might lead to the inactivation of PHD-2 and FIH-1, thereby facilitating the stabilization and transcriptional activity of HIF-1 (Koivunen et al., 2004)

Expression and significance of high-mobility group protein B1 (HMGB1) and the receptor for advanced glycation end-product (RAGE) in knee osteoarthritis

The cells were then digested with trypsin at 37C, centrifuged at 300 g for 5 min, washed with cold-PBS three times and incubated in the dark at 37C with 20 l annexin V-fluorescein isothiocyanate antibody and PI staining solution for 15 min