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To further determine the biological functions of this system, multi-dimensional experimental validation was conducted using cells, in vitro experiments, and in vivo evaluations on mice

That process is slow, and for some people it is not very efficient

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According to the Mayo Clinic, most people consume adequate amounts of B vitamins through their diet, though the elderly, particularly those with pernicious anemia, athletes, strict vegetarians, and people who consume a lot of alcohol may be deficient in the B vitamins and may require injections or oral supplementation of B vitamins or vitamin B-12, in particular