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It was demonstrated that 1.5 mM NAC significantly increased the oocyte maturation rate, the efficiency of oocyte thalamic cell expansion, and the blastocyst rate of lone female embryos, and upregulated expression of energy metabolism-related genes (SIRT1, GGCT, MITF, and IDH3G) and downregulated expression of apoptosis- and inflammation-related genes (CASP8, FOS, MMP1, CCL2, and CXCL8)

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Another randomized double-blind controlled trial confirmed that synbiotic intervention significantly decreased IL-17A protein and its mRNA expression levels in SLE patients while improving SLEDAI score, suggesting that synbiotics serve as an adjunctive therapy for SLE [93]