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As a result, certain ethnic populations may require increased administration of PGP antagonist in the formulation of the present invention to arrive at the an efficacious dose of the therapeutic (e.g., those from African descent)

This increases the risk of PIH, especially after aggressive treatments

5-HT denervation of the adult rat prefrontal cortex induces changes in the expression of alpha4 and alpha7 nicotinic acetylcholine receptor subtypes

4 (2) e4371

This affects calcium-sensitive organelles such as the mitochondria and endoplasmic reticulum [163] and causes the release of calcineurin and calpains, mediators of cell death [164]