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Validation of conformational mutant R175H in ovarian cancer cell lines APR-246 was previously reported to cause p53-independent effects through ferroptosis by affecting the redox capacity of cancer cells [27,28,29]

Our previous work has shown that CVNs receive powerful excitation from a population of hypothalamic PVN-OXT neurons that co-release OXT and GLUT to excite CVNs [28, 49, 92]

These substances not only induce physical dependence and psychological addiction but also contribute to severe neurotoxicity, manifesting as persistent cognitive impairment, emotional instability, and motor dysfunction