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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes

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The kidney is considered to be the main source for the GPx3 in plasma, which is primarily synthesized in the kidney proximal tubular cells 2,3

Inoue M, Suhara T, Sudo Y, Okubo Y, Yasuno F, Kishimoto T, et al

To be clinically translation, our group has developed a new structure small molecular drug candidate, named IMA-1, which significantly blocked NASH progression in both mice and monkeys with high safety