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For the ARISTOTLE trial population (apixaban for AF), the dose-reduction criteria require 2.5 mg twice daily when two or more of the following are present: age 80 years or older, body weight 60 kg or less, or serum creatinine 1.5 mg/dL or higher (Granger et al., NEJM 2011) [3]

Antioxidant treatment for amyotrophic lateral sclerosis

For sodium and potassium enolates diastereoselectivity of the hydroxylation was much lower (2.6:1 and 1:1, respectively)

Impact of silymarin supplements on liver enzyme levels: A systematic review

The mechanical stress from rapid injection can break peptide bonds and reduce effectiveness