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The glutamate-cysteine ligase catalytic subunit (Gcl-c), the main controlling step of GSH synthesis is less expressed in mice overexpressing PGC-1 at basal conditions

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Budiman ME, Bubenik JL, Miniard AC et al (2009) Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation

[7] Through this dual action promoting synthesis while suppressing degradation IGF-1 signaling shifts the net protein balance toward accretion in the muscle models where it has been characterized