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Reasons for the disparity in conclusions seem to be due to methodological discrepancies such as the testing protocols and the associated testretest reliability, dosing strategy (i.e., amount and timing), and the recent discovery of quality control issues with some manufacturers stated (i.e., citrulline:malate ratios)

Phase 1 breaks toxins down, and Phase 2 binds them to molecules so they can be safely eliminated

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2 Oxidants also play an important role in driving the pro-resolution pathways of inflammation by stimulating the orderly removal of spent neutrophils (efferocytosis), and modulating key cysteine residues situated on several regulatory molecules of inflammation (Figure 1)