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ROS upregulates TGF- signaling pathways and serve as critical effectors in propagating TGF--induced fibrogenic responses, including fibroblast activation, the synthesis of pro-fibrotic mediators, epithelial/endothelial cell apoptosis, and epithelial-mesenchymal transition (EMT) (Liu and Desai, 2015)

Its research profile makes it especially relevant in models focused on body-composition pathways, metabolic adaptation, food-intake signaling, satiety-related biology, and next-generation incretin-adjacent research

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

In each case, a dose of 100 l of the medication was applied to the skin on the back of a mouse