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ARG2 is mainly restricted to mitochondria and exhibits a lower affinity for L-arginine than NOS (38)

Undermethylation affects multiple core brain functions, including serotonin production, stress regulation pathways, detoxification capacity, and the ability to adapt to change

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Oral supplements build levels gradually over weeks

observed a marked increase in ACSL4 expression in a heart failure model induced by TAC in mice, and ACSL4 overexpression in cardiomyocytes exacerbates the cardiac dysfunction triggered by pressure overload through ferroptosis