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Description

AHC decreases fat production by competing with the enzyme responsible for this process

Heme oxygenase-1 (HO-1), a key regulator of heme catabolism and iron homeostasis, exerts dual roles in this process: moderate HO-1 activity confers cytoprotection through antioxidant effects, whereas excessive HO-1 expression promotes intracellular iron accumulation, oxidative stress, and ferroptotic cell death

FIGURE 7 TEM images revealed that, compared to the Control group, the Model group showed ruptured outer mitochondrial membranes, and the mitochondrial cristae were reduced or absent