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For example, MEK inhibition leads to strong overrepresentation of ERK1/2 motif as expected, GSK3 inhibition down-regulates sites that conform to the known GSK3 motif, and mTOR inhibition down-regulated sites with the known mTOR substrate motif as well as substrate sites of its main downstream kinase p70S6K

We acknowledge commenters' suggestion to implement a performance flag or annotation to indicate poor Safety of Care performance rather than a 4-star cap or 1-star reduction

FDAs 2023 Category 2 placement cited significant immunogenicity risk for some routes of administration, plus impurity and API characterization concerns